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The main assumptions for MR were as follows: (1) the genetic predictors from genome-wide association studies (GWAS) served as instrumental variables (IVs) that are strongly associated with the exposure phenotypes

References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020, GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Critically, BPC-157 alone produced no behavioral or temperature effects, confirming it acts only when the serotonin system is disturbed

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These molecules combine the targeting specificity of peptides with the potency of cytotoxic or other therapeutic agents