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Physical and psychological dependence can develop with regular therapeutic use, though the risk is lower than with recreational misuse

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Originally developed for type 2 diabetes, these drugs are now used off-label for PCOS treatment due to their ability to regulate appetite, improve blood sugar levels, and promote weight loss

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Patients with specific FTO or MC4R variants may benefit from higher protein targets or earlier dose titration schedules tailored by PlexusDx clinicians

The SURMOUNT-1 trial revealed that many tirzepatide users lost over 50 lbs , depending on starting weight