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The origins of GLP-1s trace back to foundational research in the 1980s, when scientists identified GLP-1 as a hormone critical for regulating insulin secretion and blood glucose levels.[114] Although early findings were promising, the natural form of GLP-1 degraded too rapidly in the body to serve as a viable therapeutic agent.[115] Around the same time, researchers studying the venom of the Gila monster ( Heloderma suspectum ), a lizard native to the southwestern United States, identified a hormone that slows digestion, allowing the animal to survive on just a few meals each year.[116] This research led to the discovery of exendin-4, a molecule that mimics the action of GLP-1 by stimulating insulin secretion
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Retrieved 12 March 2016
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In a separate 2 year double blinded, placebo-controlled study, weekly subcutaneous injections of semaglutide (2.4mg) in obese patients, average body weights decreased 12.6% over placebo at the 2-year point [23]
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