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Psychiatry 51 , 5564 (2017)
Ile 12 Using cryo-electron microscopy, Zhang et al found that a cluster of neighboring serines (Ser 14 , Ser 17 , and Ser 18 of GLP-1) form polar interactions with Thr 298 , the backbone oxygen of Trp 297 , and the nitrogen of Arg 299 in GLP-1R
This should not be viewed as a failure of the medication to work, but as a consequence of weight loss associated metabolic adaptation and hormonal response that results in slower metabolism and increased hunger
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Consequently, patients suffering PD commonly present with symptoms unrelated to motor function, such as cognitive decline, depression, anxiety, and sleep disturbances
Biochim Biophys Acta (BBA) - Mol Basis Dis 1453:4148
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