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[W]hen men lose significant weight, particularly in the lower abdomen or pubic area, it can uncover more of the base of the penis that was previously buried in fat, she explained

If such treatment is not tolerated or is contraindicated, a GLP-1 RA with proven cardiovascular outcomes benefit could be considered to reduce MACE and should be continued until kidney replacement therapy is indicated

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So the sequencing is the practical answer

They certainly deliver value to some: The minority of patients who are persistent long enough to achieve clinically meaningful weight loss