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Front Mol Neurosci 13:134

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Many individuals may notice improvements in overall skin radiance within 48 weeks, while more visible improvements in skin brightness and even-looking skin tone may take 812 weeks or longer of regular use

Alternative markers such as cystatin C-based eGFR or enzymatic creatinine assays may provide more accurate assessment when clinical concern exists, as recommended in KDIGO guidelines

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References Esposito MCC, Esposito ACC, Jorge MFS, DElia MPB, Miot HA