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Whilst the concentration of melatonin used in vitro far exceeds that found in vivo , in vitro conditions lead to the rapid degradation of melatonin reducing its concentration swiftly over a 24h period

DPP-4 displays numerous biological functions, such as protease activity, interaction with adenosine deaminase and the extracellular matrix proteins, co-receptor activity mediating viral entry, and regulation of intracellular signals (Kameoka et al., 1993