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Moreover, the relationship between UA levels and MS-related disability suggests that UA could be a good biomarker of MS disability and progression [159, 160]

Aging involves DNA damage, mitochondrial decline, hormonal shifts, and cellular senescence all at once

Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress

doi: 10.1111/jcmm.17099 178 WangWWangYWangFXieGLiuSLiZet al

Chemistry, physiology and pathology of free radicals

Exerkine-mediated systemic benefits may synergize with local anti-angiogenic effects, potentially improving retinal perfusion and stabilizing the BRB