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The clear winner is oral semaglutide, a GLP-1 drug now FDA-approved as a 25 mg pill for weight management since December 2025, with large human trials behind it

Important Health Conditions to Discuss People with kidney problems need careful monitoring when using either medication

Protects against Oxidative Stress: Antioxidants like Grape Seed Extract and Alpha Lipoic Acid protect the skin from free radical damage, it may reduce premature ageing and environmental harm

Consuming frequent meals with consistent timing prevents muscle breakdown from prolonged fasting

Behavioural and new pharmacological treatments for constipation: getting the balance right

Both meds can drive improved blood sugar control and potentially reduce markers of cardiovascular risk, but tolerability differs