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Initial doses are typically conservative to assess tolerability and tissue response before titration upward

To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)

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Rifabutin therapy is often used as second-,third -, or fourth-line therapy, but it carries the risk of bone marrow suppression and resistance to Mycobacterium (Deane et al., 2024

and (2) forms of vitamin E other than -tocopherol are actively metabolized and excreted