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Molecular mechanisms driving this immune activation include toll-like receptors (TLRs) and the complement system, both of which mediate microglial responses to stressors such as elevated IOP and systemic inflammation (153)

Conversely, IF promoted a substantial protection against oxidative damage in the heart

Evidence caveat: The combination approach is based on clinical observation and mechanistic reasoning, not controlled trials

This is the standard choice for most in vivo preclinical protocols

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Age and Demographic Considerations Clinical trials for both compounds have primarily enrolled adults aged 18-75 with specific metabolic profiles