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Excessive oxidation of GDH leads to a decrease of glutamate in hepatocytes, which in turn reduces the production of N-acetylglutamate (NAG), an allosteric activator of carbamoyl phosphate synthetase (CPS)

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For example, one study saw no significant difference in serum folate levels of patients with diffuse hair loss compared to controls

When taken together, these findings highlight the need for caution in assuming that every compound that is produced by the body is good

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