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Amino.Acids 2008;35(2):419-423
A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder
The studies tested various doses including 0.25 mg, 0.5 mg, and 1 mg daily via subcutaneous administration over periods ranging from single doses to 24 weeks of continuous therapy
Hence, while the complete picture of how the combination works is still unclear, there is evidence supporting that it entails common signaling pathways
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