While its mechanism suggests it could lighten skin, only three small studies have tested it, and their follow-up periods were short
Nrf 2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): novel mechanistic considerations
IV protocols: 6002,000 mg per session, 12 times weekly
(2017) conducted a randomized, double-blind, placebo-controlled crossover trial in 40 healthy adults, showing that 15 mg/day HTY for 3 weeks significantly increased plasma thiols, total antioxidant status, and SOD1 expression while reducing nitrite, nitrate, and MDA, and modestly lowering body fat mass, supporting HTYs anti-atherosclerotic and cardioprotective potential via improved redox balance and gene expression modulation [77]
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety