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Interaction with metformin or berberine (both AMPK activators) appears synergistic rather than competitive

The proportion of participants achieving 20% or greater weight loss was 36% at the 10mg dose and 40% at the 15mg dose, results approaching what was previously achievable only with bariatric surgery

Numerous studies have shown that poorer quality diets, such as the Western diet, can lower Lactobacillus levels, reduce the richness of the entire microbial community, and be associated with depression risk susceptibility (155)

It is important to distinguish between evidence-based medical treatment for deficiency and unsubstantiated claims regarding weight management

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