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In this study, histopathological examination of both right sides in two groups was of great value not only in confirming the type of melasma but also adding another objective tool in evaluation of treatment response in two groups, it demonstrated a decrease in melanin in basal cell layer in epidermal types and in melanin and melanophages in dermis in mixed types in H and E and MF stained sections after treatment compared with baseline

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Healing is a holistic process

It is primarily driven by the development of hypertrophy in the afferent arteriole, which compromises autoregulation and facilitates heightened transmission of systemic blood pressure to the glomerulus

Gradual increases allow the body to adjust while doctors monitor for relief

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