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Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons
Splitting the dose does not
Remarkably, semaglutide markedly improved hepatic steatosis, fibrosis, and immune remodeling in the absence of weight reduction. In a further test, mice lacking LSEC receptors showed no liver improvement on semaglutide even after losing 20% of their body weight
Injection site bruising occurs when the needle inadvertently punctures small blood vessels during subcutaneous injection, causing blood to leak into surrounding tissue
While further studies are underway to assess their efficacy for opioid, cocaine, and stimulant use disorders, current findings suggest that GLP-1 RAs may offer new avenues for addressing maladaptive reward-driven behaviors beyond obesity
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