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Monitoring and recognition: Patients taking Ozempic alongside insulin or sulfonylureas should monitor blood glucose levels regularly , particularly when experiencing symptoms of faintness

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A 9-week, placebo-controlled study of 48 adults with alcohol use disorder demonstrated that once-weekly semaglutide reduced alcohol self-administration in the laboratory (, 0.48 [95% CI, 0.85 to 0.11];P = .01), craving (, 0.39 [95%CI, 0.73 to 0.06];P = .01), and drinks per drinking day (, 0.41 [95% CI, 0.73 to 0.09]

However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254