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IGF-1 Elevation Increased HGH stimulates the liver to produce IGF-1, the downstream mediator responsible for many of growth hormone's tissue-level effects

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However, its relatively short plasma half-life of 23 min, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4), has prompted structural modifications to enhance its pharmacological efficacy

Researchers also noticed another effect people taking Wellbutrin experienced: modest weight loss