[Abstract]2026 Jun 8:2026.06.03.729910
According to the FDA Prescribing Information, you should consider discontinuing Zepbound at least 1 month before a planned pregnancy due to the long washout period and limited data on fetal effects
Reconstitute the full amount, divide into weekly aliquots in sterile glass vials, freeze all except the current week portion, and thaw one new aliquot each week
Values come from 225 study results, La Vignera et al., Reproductive Biology and Endocrinology Group A Tirzepatide + Lifestyle Medication & Dose: Weekly tirzepatide injections (2.5 mg in the first month, increased to 5 mg the following month)
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Tolerability matters for long-term adherence