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To date, most of the in vitro and in vivo evidence for the potential of MC drugs in fibroblast-driven diseases have been conducted using the natural agonist MSH, but the time is ripe to move forward into testing improved synthetic analogues and small molecules with higher pharmacokinetic and pharmacodynamic profiles to provide hopes for the effective management of countless diseases with high needs involving dysregulated fibroblasts

Inhibition of receptor interacting protein kinases attenuates cardiomyocyte hypertrophy induced by palmitic acid

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Arakawa M, Mita T, Azuma K et al (2010) Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like

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Both heterozygous patients with partial pathway impairment and homozygous patients with complete LOF mutations achieve clinically significant weight reduction (approximately 5%-10% from baseline) and experience marked reductions in hyperphagia