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Celiac disease and Crohns disease patients may not be able to absorb enough B12 from food.
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme present in every living cell
doi:10.2174/157340313805076322 Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R
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As a result, it can take more than 48 hours for cyanocobalamin to eventually convert to usable B12, and even then only a small amount of converted and absorbed