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However, as discussed in section Review of 1 H MRS Studies Evaluating Glutamate or Glx, GABA, and Glutathione in ALS, there are significant limitations in methodology and experimental design, the number of studies to date, and the Glx/NAA and GABA/Glx ratios not being directly reported in studies

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Pulse Sequence and Magnetic Field Strength Methodology One limitation in assessing the 1 H-MRS glutamate biomarker is the ability to control for the varying MRS methods that were used across the studies assessed, as shown in Table 4

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