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The changes observed at week 68 from STEP 1 trial were assumed to be maintained for total cholesterol and HDL change as assessment of these risk factors was not performed at this time point

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Computational methodologies, such as network pharmacogenomics, pathway enrichment analyses, and the reconstruction of pathway-pathway comorbidity networks, have provided valuable insights into the pathological mechanisms underlying diseases, including comorbidities and the influence of environmental factors such as viral and bacterial infections in disease development and/or progression 19,20,21,22,23,24