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A large outcomes trial showed better weight loss and risk factor improvement compared with semaglutide, summarized in an American College of Cardiology trial review

[1] [5] For weight management, semaglutide is not recommended during pregnancy

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So, although SGLT2 inhibitors are considered to act mainly through the kidneys, their effects on the microbiome deserve further evaluation

8 Although the brain is not dependent on insulin for glucose uptake, insulin receptors have been detected in the hypothalamus, olfactory bulb, retina, hippocampus, vessels of the choroid plexus and regions of the striatum and cerebral cortex

En este captulo, abordaremos de manera resumida el impacto teraputico de los frmacos con accin sobre el receptor del pptido similar al glucagn tipo 1 (GLP-1) en el tratamiento de la obesidad y sus comorbilidades