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3 As FDA-approved treatments for T2D and chronic weight management, semaglutide and tirzepatide have demonstrated significant weight reductions in randomized clinical trials among individuals with obesity compared with other FDA-approved obesity treatments

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For example, chronic IH dysregulates the expression and activity of eNOS, disrupting NO production and, thus, contributing to the development of ECD

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GLP-1 is a peptide secreted by L-type enteroendocrine cells in the ileum and colon in response to different nutrients, mainly glucose and lipids, whereas glucose-dependent insulinotropic polypeptide is produced by K cells present in the duodenum and the first portion of the jejunum