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For skin-specific research, topical delivery has four practical advantages that shape research protocol design
Choline: Similar to L-carnitine, high doses increase the production of TMAO
an alternative funded GLP-1 receptor agonist) Vildagliptin (oral, funded), taken either as separate metformin and vildagliptin tablets, or a combination vildagliptin + metformin formulation A sulfonylurea (oral, funded), such as gliclazide or glipizide Pioglitazone (oral, funded) The decision about which medicine to use should take into account any contraindications, cardiovascular co-morbidities, risk of hypoglycaemia, effects on weight, medicines interactions, adverse effects and eligibility for funding (Table 2 and Initiating funded treatment)
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