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Consistent with a mtGSH-dependent mechanism, chemical depletion of mtGSH with a mitochondrially-targeted CDNB phenocopied these defects, whereas partial rescue by a cell-permeable GSH ester restored pro-IL-1

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Inactivation of NOX decreases ROS production and prolongs survival in SOD1 G93A mice (Seredenina et al., 2016), and may modify survival in ALS patients (Marrali et al., 2014)