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However, individual responses vary considerably, and gradual dose titration is essential for all GLP-1 preparations

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In addition, adipose tissue secretes proinflammatory cytokines, including tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), which may impair neuromuscular control and exacerbate nocturnal respiratory instability (9, 10)

The emergence of oral GLP-1s, once-monthly injectables, dual- and triple-receptor targets and combination therapies has enhanced patient convenience, improved adherence and broadened clinical utility, bringing healthcare practitioners more options for individualized treatment

Hematoxylin and eosin staining The Hematoxylin and eosin (HE) staining was performed as previous report 29