Emerging Concerns: 2025 observational data suggest a potential 0.05-0.1% risk of hypercoagulability with mega-doses in predisposed individuals, under investigation in phase 2 trials by 2026
While this study was not a head-to-head clinical trial comparison, it may be relevant that at week 12 of a weekly dosing regimen, some studies suggest that participants treated with semaglutide (Wegovy, Novo Nordisk) had an approximately 6% decrease from baseline in body weight, whereas those treated with tirzepatide (Zepbound, Eli Lilly) had an approximately 8% decrease from baseline in body weight at the same time period, Bays said
Enhanced Penile Strength : By promoting tissue regeneration, the P-Shot can strengthen the structure of the penis, potentially leading to firmer erections and improved sexual performance
Prior Authorization Requirements When Anthem does cover Wegovy or Zepbound, it typically requires prior authorization: Clinical Requirements BMI of 30 or higher, OR BMI of 27 or higher with at least one weight-related condition Documentation Requirements Medical records supporting the diagnosis Evidence of previous weight loss attempts Sometimes: trial of other weight loss medications first (step therapy) Initial approval period: Typically 6 to 12 months
Thus, with vitamin C being water-soluble, most of the vitamin C that people on the regimen were paying to consume was being excreted in the urine, thus making it expensive
1991 May 8;57(2):91-4