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doi: 10.1016/j.nano.2009.07.002 179 TheuretzbacherU.OuttersonK.EngelA.KarlnA

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We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

A landmark randomized, cross-over clinical trial published in the International Journal of Clinical Nutrition & Dietetics by [Fanelli et al

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PubMed Hsieh, M.J., Liu, H.T., Wang, C.N., Huang, H.Y., Lin, Y., Ko, Y.S., Wang, J.S., Chang, V.H., & Pang, J.H