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Combination therapies, such as Miltefosine with Paromomycin or liposomal Amphotericin B, are also being investigated to improve effectiveness and reduce treatment duration ( Nanoparticle formulations of Amphotericin B, including topical options, are being trialed for safer, localized treatment of CL lesions ( 7 Emerging drug targets in Leishmania Recent advances in molecular and cellular biology have identified several promising drug targets that could pave the way for novel therapeutic interventions ( Leishmania parasites, suggesting its potential as a therapeutic target for visceral leishmaniasis (Wyllie et al., 2018)

A nutrient-rich diet especially one high in sulfur-rich foods can naturally enhance glutathione levels

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For cell immunostaining, HeLa cells were transfected with different plasmids for 12 h and fixed in 4% paraformaldehyde for 1 h at room temperature

Common side effects (may affect up to 1 in 10 people): * Pain, redness, or swelling at the injection site * Nausea * Headache Uncommon side effects (may affect up to 1 in 100 people): * Diarrhea * Dizziness * Allergic reactions such as skin rash, itching, or hives Rare side effects (may affect up to 1 in 1,000 people): * Severe allergic reaction (anaphylaxis) with symptoms like difficulty breathing, swelling of the face or throat, and a drop in blood pressure