uses of glutathione injection Benefits, and Best Practices Glutathione Injection: Benefits, Uses &

K.JamesD.et al (2018)

222 As a Lewy body constituent and a partner of alpha-synuclein, synphilin-1 interacts with -synuclein to diminish the degeneration of neurons in the brain and motor abnormalities in mice with the A53T mutation

These symptoms occur because excess glutathione can increase glutamate levels (an excitatory neurotransmitter)

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If the cell cannot recycle GSSG back into GSH fast enough using an enzyme called glutathione reductase, the cell enters a state of toxic oxidative stress, leading to mitochondrial damage and, eventually, programmed cell death (apoptosis)

As NAD + is the precursor of NADH, the low levels of both metabolites suggest NAD + depletion while the NAD + /NADH ratio remained unchanged in most of the diseases (Fig