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doi: 10.1021/bi000497p 63 SunWChenL-NZhouQZhaoL-HYangDZhangHet al

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Efficacy and safety of dapagliflozin in patients with acute heart failure

Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism