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GLP-1 RAs bypass genetic defects in the leptin-melanocortin system, promote weight loss, and improve metabolic function through the coordinated regulation of blood glucose and appetite [64,65] [Figure 2]
Semaglutide can be taken with other diabetes medications if prescribed by the doctor
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Therefore, further studies are needed for a better definition of the effects of LC on SPARC, decorin, and TMAO levels in vivo in humans
CCL, C-C chemokine ligand
A 2024 randomised trial showed semaglutide reduced hip bone mineral density by 2.6% and lumbar spine density by 2.1% at 52 weeks compared with placebo, in adults already at increased fracture risk
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