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The numbers: The subjects on semaglutide had an average change in weight of -13.7%, while those taking tirzepatide saw a decrease of -20.2%

Some taste like you're licking a salt block (and when you already have nausea from your meds, that's a non-starter)

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Most patients experience noticeable appetite increases within two to four weeks and measurable weight regain within eight to twelve weeks of stopping treatment

Patients were followed for a median of 34.7 months

Top pick: MyRocky (operated by Rocky Health Inc.) is our highest-rated Canadian GLP-1 provider in 2026 ( 9.4/10 )