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No controlled human-lifespan trial was identified

Although all studies used randomization

A 2022 study published in JAMA Network Open found that people taking antidepressants experienced somewhat reduced weight loss with GLP-1 medications compared to those not taking antidepressants

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Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA (32)