How do you evaluate permeability risk when assessing a new chemical series
If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss alternative treatments with your doctor
1 Heart rate and irregular heartbeats Retatrutides effects on the heart are part of its safety profile that clinicians and regulators are watching most closely.1,2 Theyre also one of the main reasons regulators want full long-term data before the drug is widely used
Kazamel M, Stino AM, Smith AG (2021) Metabolic syndrome and peripheral neuropathy
Key risks include worsened gastrointestinal side effects (nausea, vomiting), hypoglycaemia (particularly in patients taking insulin or sulfonylureas), dehydration, inadequate nutritional intake, and potential exacerbation of pancreatitis or gallbladder problems
Nat Med 2013 , 19 , 576585