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Gene ontology (GO) molecular function analysis showed that several downregulated functions such as glutathione peroxidase activity, glutathione binding, and glutathione transferase activity in YTHDF1 KO group (Fig
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[125] In 2016 Imai expanded his hypothesis to "NAD World 2.0", which postulates that extracellular NAMPT from adipose tissue maintains NAD + in the hypothalamus (the control center) in conjunction with myokines from skeletal muscle cells
