The current branded form, Egrifta WR, was FDA-approved in March 2025 and became available in September 2025
Redox Biol 36:101679 Albano GD, Gagliardo RP, Montalbano AM, Profita M (2022) Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases
Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]
Maintenance: Return to 600 mcg daily for Weeks 58+
Room temperature medication is less viscous, flows more smoothly through the needle, and causes less tissue irritation upon injection
In a deal worth up to $285 million initially for the lead program, Novo Nordisk will gain access to Ascendis TransCon technology platform in an effort to find novel GLP-1 candidates with reduced dosing frequency