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NICE guidance does not mandate preference for daily versus weekly formulations but recommends individualising treatment choice based on patient factors including: Lifestyle and convenience : Weekly injections may suit busy schedules Tolerability : Some patients experience fewer gastrointestinal side effects with certain formulations Clinical efficacy : Specific medications may provide better glucose control or weight loss for individual patients Cost-effectiveness : NHS formularies may influence availability Your GP or diabetes specialist nurse will discuss which dosing schedule best suits your circumstances, taking into account your treatment goals and personal preferences