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Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

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doi: 10.3748/wjg.v12.i26.4117 61 MunroeDGGuptaAKKoosheshFVyasTBRizkallaGWangHet al

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One concern with any new treatment approach is tolerability, particularly for a population already dealing with complex health challenges