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SHH has previously been identified as a critical signal for the maintenance and renewal of taste cells, while PLC-2 is a marker involved in sweet, umami, and bitter signaling within type II cells, which may contribute to reduced sensitivity to taste stimuli (107)

GLP-1 medications can make thirst less reliable, and gastrointestinal side effects can change fluid balance

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10.1016/j.autneu.2009.08.002 16 BertrandP