The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
It has the unique ability to cross the blood-brain barrier, making it ideal for therapeutic applications
This combination produces synergistic healing effects exceeding either peptide individually by approximately 30% according to user reports
Both with the use of corticosteroids and with the use of ginseng, it would be necessary to consider supplementation with DHEA, since the use of corticosteroids inhibits ACTH secretion and therefore the production of DHEA and DHEA-S (174, 255)
M., Nyberg, E., Jones, I
This is equal to a 2mg dose for a 175lb person [3, 11]