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There are two types of prescription only vitamin B12 medicines that are listed in the British National Formulary (BNF) by NICE (National Institute for Health and Care Excellence) to be used for treating vitamin B12 deficiencies hydroxocobalamin and cyanocobalamin

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For example, certain biological products or drugs (like some vaccines or delicate protein-based drugs) should not be reconstituted with bacteriostatic water because the preservative could interfere with the drugs stability or efficacy

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10 A number of studies have investigated sublingual administration, and all found sublingual B12 to be effective in normalising B12 status in deficient adults, 11,12,13,14 infants 15 and children