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The history of KPV is closely tied to the study of the alpha-melanocyte-stimulating hormone (-MSH), a peptide hormone known for its role in pigmentation, inflammation, and immune modulation
This allows researchers to test a range of doses on a smaller cohort, identifying the minimum effective dose and any potential adverse effects before committing to a larger, more resource-intensive study
(Body Protection Compound-157) is a synthetic pentadecapeptide investigated mainly in cells and animal models for effects on tissue repair biology, angiogenesis, and gastrointestinal integrity
Sikiric did not respond to repeated requests to share data from the trial
Sequences of primers for qRT-PCR are listed in Supplementary Table 2