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The drug also produced positive effects on the amount of fat: Abdominal fat pads were 40 percent smaller in the animals that received either a low or high dose of Melanotan II compared with those that did not, and it appears that those effects were independent of caloric restriction

4.3 Microbial translocation and disruption of the intestinal barrier In the process by which pathogenic symbionts (pathobionts) induce IBD, the stability of the gut microbiota is crucial