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Glucagon-like peptide-1 agonists reduce cardiovascular events in cancer patients on immune checkpoint inhibitors

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An imbalance in the microbiota may shift the metabolic pathway of tryptophan, leading to a reduction in 5-HT production and contributing to the onset of depressive symptoms [498,499,500]

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30 To further confirm that these hepatic abnormalities were directly attributable to NF1 deficiency rather than patient-specific background, we generated an isogenic control by restoring NF1 expression in patient-derived iPSCs using a lentiviral NF1-AON strategy (Supplementary Fig

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