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Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)
In this process, Glutathione generates in higher quantity
2014;44 Suppl 2:S167-73
Cancer cells often reduce iron release by upregulating transferrin receptor 1 (TfR1) or inhibiting membrane iron transporter, or increase iron uptake through these mechanisms to sustain cell proliferation
If any side effects are severe, persistent, or significantly affecting quality of life or nutritional intake, contact your GP or prescribing clinician promptly
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