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Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]
Think of it as a next-generation version of drugs like Ozempic (which hits one receptor) and Zepbound (which hits two)
3.67 times higher risk of gastroparesis, or stomach paralysis, which limits the passage of food from the stomach to the small intestine and results in symptoms like vomiting, nausea and abdominal pain
2019 Oct;75:105732
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Dr Adrian, a functional medicine doctor and MD specializing in thyroid, PCOS, and gut health, recently shared on Instagram a list of foods that may work in a similar way
